Science and research

Department of Molecular Genetics

The main mission of our laboratory is to provide regular molecular monitoring of the minimal residual disease (MRD) in patients with chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) , and the detection of mutations in the kinase domain of BCR-ABL that are one of the mechanisms of resistance to the treatment with tyrosine kinase inhibitors. Furthermore, we co-operate with laboratories in other countries on the standardization of the monitoring of MRD and participate in several clinical trials.

Our research is aimed at improving the molecular diagnostics of CML for clinical practice (e.g. detection of MRD and detection of resistant mutations). We have been striving to enhance our understanding of, and to detect in time, with clinical relevance, the resistance to the treatment (in vitro and in vivo research). Our research projects also focus on other molecular mechanisms of the disease (e.g. the role of microRNA and transcription factors, CML stem cell).  Physicians, nurses as well as data managers from the Clinical Department, headed by Dr.  Hana Klamová, are an integral part of our team.

Quick contact

Head of Science and Research Division
Tel:+420 221 977 208

Deputy head of Science and Research Division
Tel:+420 221 977 269
Tel:+420 221 977 364

Tel:+420 221 977 247

Opening hours

Mo – Fr: 7:00–18:00
Weekends: 9:00–13:00

Mo – Fr: 7:00–10:30

Inpatient department
Mo – Fr: 13:00–18:00

ICU and Transplant unit
Mo – Fr: 14:00–17:00

How to find us


Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 00 Praha 2

The nearest underground station: Karlovo náměstí (line B)

The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)

The nearest bus station: U Nemocnice (148), Karlovo náměstí (176)

How to get here