Úsek pro vědu a výzkum

Academic Clinical Trials

UHKT-CAML-NK-01
EudraCT: 2017-001119-35

"Adoptive transfer of haploidentical ex-vivo expanded NK cells to patients with refractory or relapsed acute myeloid leukemia in allogeneic hematopoietic stem cell transplantation from a haploidentical related donor following a sequential preparatory protocol.  A monocentric, open-label, phase IIa study with escalating dosing."

Finished

UHKT-VSL-CCS-01
EudraCT: 2018-004789-32

"Efficiency of production, clinical safety and efficacy of virus-specific T lymphocytes isolated on the CliniMACS Prodigy® device using the Cytokine Capture system for patients after allogeneic transplantation."

Finished

TCB-202-001
EudraCT: 2018-000409-22

"Clinical evaluation of the safety and efficacy of allogeneic γδ T-lymphocytes expanded ex vivo (OmnImmune®) in patients with relapsed or refractory acute myeloid leukemia (AML) who are unable or unwilling to undergo high-dose rescue chemotherapy and/or allogeneic hematopoietic cell transplantation. An open-label, dose escalating phase I study."
https://pubmed.ncbi.nlm.nih.gov/36863897/

Finished

UHKT-CAR19-01
EudraCT: 2018-004789-32
EU CT number: 2024-510815-30-00
Clinicaltrials.gov ID: NCT05054257

"Clinical evaluation of the safety and efficacy of autologous CART19 lymphocytes in patients with relapsed or refractory acute B-lymphoblastic leukemia (B-ALL) or relapsed or refractory B-cell non-Hodgkin's lymphoma (B-NHL).  An open-label, dose-escalating phase I study."

Open

UHKT-CAR123-01
EU CT number: 2022-503165-30-00

"Safety and efficacy of autologous T lymphocytes with chimeric anti-CD123 antigen receptor in patients with relapsed or refractory CD123-positive hematologic malignancies. An open-label, dose-escalating phase I study."

Open