Research Division

The common basis of many projects solved in the research laboratories of the Institute of Haematology and Cancer Research is the analysis of molecular mechanisms of the origin and development of haemato-oncological disorders, laboratory monitoring of the effects of clinically used procedures and drugs.

A number of research projects deal with the issues of blood clotting, congenital defects of hematopoiesis and the development of new therapeutic procedures based on the support of immune system function.

Modern techniques in genomics, cytogenetics, molecular genetics, proteomics, metabolomics, cell and molecular biology and immunology are used.

An important part of the work of the research department is the development and implementation of new diagnostic methods for clinical practice.

The Research Department consists of eight research departments and a grants department:

Areas of science and research:

Chronic myeloid leukaemia (CML)

Mechanisms of resistance to treatment with tyrosine kinase inhibitors and transformation to blastic reversal - development of mutations in the BCR-ABL kinase domain, deregulation of epigenetic factors and tumor-suppressor genes, role of molecular chaperones, other molecular changes in drug-resistant CML cells
New approaches in molecular diagnosis and monitoring of residual disease in CML patients

Myelodysplastic syndrome (MDS)

Monitoring clonal evolution in MDS
Identification and clinical implementation of novel molecular markers of response to newly introduced therapeutic approaches
Genome-wide expression profiling of long non-coding RNAs in MDS
Circulating plasma miRNAs as molecular biomarkers of MDS

Acute myeloid leukemia (AML)

Study of mutations and clonality of leukemia cells in AML patients
Effect of C-terminal mutations on nucleophosmin function and immunogenicity
Frequency and significance of dicentric chromosomes in the karyotype of patients with myeloid diseases

The function of the immune system in hematooncology

Development of experimental therapeutic approaches and vaccines against CML
Gene modifications of T cell receptors for cancer therapy - development of a new generation of CARs
Adoptive immunotherapy - selection and cultivation of antiviral T-lymphocytes and development of antiviral CARs
Investigation of the immunological profile of CML patients and its changes during therapy.
Reconstitution of cellular immunity against human cytomegalovirus in patients after bone marrow transplantation

Thrombosis and haemostasis

Study of the structure and function of platelets and blood proteins involved in haemostasis (arrest of bleeding) and thrombosis
Congenital and acquired dysfibrinogenemias and hypofibrinogenemias
Biochemical, genetic and morphological analogues of neurovascular and cardiovascular ischemic diseases

Other research and development topics

Surface plasmon biosensors and protein chips for medical diagnostics
Iron absorption and processing in the human body
Blood cell adhesion structures and signaling pathways regulating their interaction with the extracellular matrix
New methods for the diagnosis of hereditary spherocytosis
Epidemiological studies based on molecular biological and serological markers of papillomavirus and polyomavirus infection in relation to human cancer
Prevalence of papillomavirus infection in relation to vaccination with preventive human papillomavirus vaccines
Changes in the prevalence of markers of infection with small DNA viruses in relation to the course of immunosuppression after hematopoietic stem cell transplantation for the treatment of leukemia
Development of immunization therapeutic approaches based on influencing non-specific immunity and the tumor microenvironment
Tumor markers associated with resistance to immune mechanisms and progression of tumorigenicity