Development of new methods of cell and gene therapy of hematological malignancies
Thrombosis and Hemostasis
Hemophilia, von Willebrand disease, and rare disorders of hemostasis
Other rare blood diseases
Iron metabolism
Hematopoietic cell transplantation
Areas of applied research and technology transfer
The main research topics
Monitoring genome and gene expression in onco-hematological diseases
Studying protein expression (proteome) and protein interactions (interactome and complexome) in leukemic cells and their changes related to malignancies
Studying the pathogenesis of myelodysplastic syndrome (MDS)
Studying the pathogenesis of chronic myeloid leukemia (CML) and its resistance to its treatment
Looking for targeted therapies for CML cells resistant to common therapy
Congenital diseases of hematopoiesis
Studying methylation and acetylation as epigenetic mechanisms that complement each other and regulate gene and protein expression in cells
Biosensors with surface plasmons and protein microarrays for medical diagnostics
Proteome analysis of the effects of administered pharmacological drugs (imatinib mesylate, dasatinib, saracatinib, SAHA – suberoylanilide hydroxamic acid) on human blood cells
The role of cytokines in the development of graft-versus-host disease (GVHD) after the allogeneic transplantation of hemopoietic stem cells
Research into DNA tumor viruses
Developing immunotherapeutic strategies and vaccines for CML and AML on mouse models
Studying adhesion structures and signalling pathways controlling cell adhesion to the extracellular matrix and cell migration of blood cells
Studying iron absorption and metabolism in the human body
Epidemiological studies based on molecular-biological and serological markers of papillomavirus and polyomavirus infections related to human malignancies
The Research Division consists of seven departments:
