Department of Genomics

We perform the detection of mutations in NPM1, CEBPA and TP53 genes. Further, we measure the gene expression levels of WT1, BAALC, PRAME and mutated NPM1 in order to monitor minimal residual disease. Equally important are our research activities aimed at understanding the development and evolution of these diseases, and the identification of new sensitive molecular markers that may be used in clinical diagnostics to improve patient care.

Main current topics

• MicroRNAs in Myelodysplastic Syndromes
• Long Non-Coding RNAs in Myelodysplastic Syndromes
• National Study of Mutations, Clonality and DNA Methylation in Patients With Acute Myeloid Leukemia – Collaborative Project with Faculty Hospital Brno
• Cereblon Expression in Lower-Risk Myelodysplastic Syndromes
• DNA Repair Systems in Myelodysplastic Syndromes
• NPM1 and CEBPA Mutations
• Minimal Residual Disease (MRD) Monitoring

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