OPPC: Modernization of Equipment for Proteomics, Metabolomics, and Immunomonitoring in the Research Laboratories of UHKTP
Prague & EU: Investing in your future
European Regional Development Fund
Registration number: CZ.2.16/3.1.00/24001
Number in CES: INO/02/01/001668/2010
The project is implemented under the 4th call of the Operational Programme Prague - Competitiveness, Support area 3.1: Development of innovation environment and partnership between R&D base and practice.
The project is intended for the Institute of Haematology and Blood Transfusion, for the laboratories of the research section, which are part of the Department of Biochemistry, Cell Physiology, Cell Biochemistry and Experimental Virology. The research activities carried out here are covered by public funding for science and research.
The partners of the project are three academic research institutes from the non-profit sector, which have long-standing and successful cooperation on research projects with IHBT.
- Faculty of Mathematics and Physics, Charles University in Prague
- Institute of Molecular Genetics
- University of Chemical Technology (VŠCHT), Faculty of Food and Biochemical Technology (FPBT)
Project start date: 1.11.2010
Project end date: 31.10.2012
Duration: 24 months
The aim of the project is to renew and modernize the technical base of basic research laboratories so that the results of this activity contribute to the development of methods for early diagnosis of oncological and haemato-oncological patients, to the development of knowledge on the pathogenesis of cancer, to the development of molecularly targeted cancer treatment and to the development of cancer immunotherapy. Meeting the project objective will lead to the development of new disciplines such as proteomics metabolomics and immunological therapeutics.
The modernisation will include equipping the laboratories with new equipment - the purchase of these instruments:
- Multiplex system for protein detection
- Triple Quadrupole Mass Spectrometer (MS/MS)
- Flow cytometer
- Confocal microscope
- Chemiluminescence imaging and documentation system
- Real-time PCR system
- ELISPOT reader
The reason for the project implementation is to increase the applicant's competitiveness in the field of therapeutic and preventive activities, to increase the quality of scientific research activities, to increase the competitiveness of other entities (using research outputs), to increase the quality of treatment of the population and to increase the attractiveness and prestige of the IHBT for young scientists. The modernisation of equipment will enable the expansion of research activities that are currently covered by domestic grant agencies.
The successful implementation of the project will address the shortcomings in the equipment of the laboratories of the IHBT through the purchase of 7 state-of-the-art instruments and equipment. The department will thus be able to carry out a number of research tasks that will lead to the application of translational medicine and link basic research (carried out within the project) with applied research.
Within the Institute of Haematology and Blood Transfusion, the project will contribute during its operational phase:
- to maintain and improve the quality of its therapeutic and preventive activities, which will maintain and improve its position, already comparable to similar institutions in the European Union
- increased efficiency of research activities
- improved diagnosis of haemato-oncology patients, which will improve their subsequent prognosis and care
- the application of translational medicine and the linking of applied research with basic research
- to improve access to new technologies, not only for the IHBT, but also for a number of collaborating organisations
- to be more competitive in obtaining grant funding
The project indicators have now been met by the implementation of the following points:
- 7 state-of-the-art instruments and equipment have been purchased with public funds
- the creation of "Procedures for the monitoring of medicines", which are available to all those involved in the field
- the results obtained with the support of the project have been published in 21 publications in scientific journals