Quick contact
Head of Science and Research Division
Tel:+420 221 977 208
Deputy head of Science and Research Division
Tel:+420 221 977 269
Tel:+420 221 977 364
Secretary
Tel:+420 221 977 247
Institute of Hematology and Blood Transfusion
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. LncRNAs have been recently recognized as the hallmark features in various diseases. In hematopoiesis, they regulate development at almost every stage of cell lineage differentiation; therefore, abnormal expression of lncRNAs may lead to different hematopoietic disorders. Until now there has been almost no information available about lncRNA deregulation and role in myelodysplastic syndromes (MDS).
We perform genome-wide screening of lncRNA levels in MDS patients and compare expression profiles between various risk groups of patients and healthy subjects, to find lncRNAs with altered levels in MDS. This knowledge will help us to better understand the pathogenesis of MDS and identify lncRNAs that may represent candidate diagnostic and prognostic molecular markers of the disease.
Head of Science and Research Division
Tel:+420 221 977 208
Deputy head of Science and Research Division
Tel:+420 221 977 269
Tel:+420 221 977 364
Secretary
Tel:+420 221 977 247
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Ústav hematologie a krevní transfuze
(Institute of Hematology and Blood Transfusion)
U Nemocnice 2094/1
128 00 Praha 2
The nearest underground station: Karlovo náměstí (line B)
The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)
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