Science and research

Department of Biochemistry

The Department of Biochemistry studies the structure and functions of blood platelets and blood proteins which play a role in hemostasis and thrombosis, the hemocompatibility of biomaterials, and the proteomics of onco-hematologic disorders.

The key methodologies are proteomics, interactomics, complexomics and metabolomics. Molecular biology and mass spectrometry (MS) methods are used to monitor hypofibrinogenemia as well as congenital and acquired dysfibrinogenemia in the long term.

Proteomic methods are being developed, particularly the construction of protein biochip arrays using surface protein resonance optical detection. Analysis of subproteomes in human plasma proteins and blood corpuscles is conducted, we look for differences in the expression of proteins and their post-translation modifications to better understand the pathogenesis of onco-hematological diseases. In the last 8 years, the Department has identified 46 new cases of acquired afibrinogenemia and three cases of congenital afibrinogenemia.

Quick contact

Head of Science and Research Division
Tel:+420 221 977 208

Deputy head of Science and Research Division
Tel:+420 221 977 269
Tel:+420 221 977 364

Tel:+420 221 977 247

Opening hours

Mo – Fr: 7:00–18:00
Weekends: 9:00–13:00

Mo – Fr: 7:00–10:30

Inpatient department
Mo – Fr: 13:00–18:00

ICU and Transplant unit
Mo – Fr: 14:00–17:00

How to find us


Ústav hematologie a krevní transfuze
(​Institute of Hematology and Blood Transfusion)

U Nemocnice 2094/1
128 00 Praha 2

The nearest underground station: Karlovo náměstí (line B)

The nearest tram station: Karlovo náměstí (10, 16, 22), Moráň (3, 6, 10, 16, 18, 24)

The nearest bus station: U Nemocnice (148), Karlovo náměstí (176)

How to get here